Short DNA sequence patterns accurately identify broadly active human enhancers

Abstract

Enhancers are DNA regulatory elements that influence gene expression. There is substantial diversity in enhancers’ activity patterns: some enhancers drive expression in a single cellular context, while others are active across many. Sequence characteristics, such as transcription factor (TF) binding motifs, influence the activity patterns of regulatory… (More)
DOI: 10.1186/s12864-017-3934-9

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