Short Communication Repeated Imipramine Administration Enhances the Effects of Nmda Receptor Ligands on Synchronous Activity in Rat Frontal Cortex in Vitro

Abstract

This study assessed the effects of repeated administration (14 days) of imipramine on the function of NMDA receptors by measuring the frequency of spontaneous epileptiform discharges which develop in rat frontal cortical slices incubated in Mg -free conditions. Imipramine significantly enhanced both the excitatory effect of NMDA and the inhibitory effect of the competitive NMDA receptor antagonist CGP 37849 on the frequency of discharges. These results are consistent with studies indicating that chronic administration of antidepressant drugs induces adaptive changes in NMDA receptor/ channel complex in the cerebral cortex.

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Cite this paper

@inproceedings{Bobula2002ShortCR, title={Short Communication Repeated Imipramine Administration Enhances the Effects of Nmda Receptor Ligands on Synchronous Activity in Rat Frontal Cortex in Vitro}, author={Bartosz Bobula and Krzysztof Tokarski and Grzegorz Hess}, year={2002} }