Short Communication Cinromide's Metabolite in Monkey Model: Gastric Administration and Seizure Control

@article{Lockard1980ShortCC,
  title={Short Communication Cinromide's Metabolite in Monkey Model: Gastric Administration and Seizure Control},
  author={J. Lockard and R. Levy and L. L. DuCharme and W. C. Congdon},
  journal={Epilepsia},
  year={1980},
  volume={21}
}
Summary: In a previous study (Lockard et al., 1979) Cinromide (3 bromo‐N‐ethylcinnamamide), an experimental anticonvulsant (Burroughs‐Wellcome Pharmaceutical Co.), was given a preliminary evaluation. Since that research was concerned primarily with EEG paroxysms, the present study was conducted to address drug efficacy in terms of clinical seizures. Cinromide's major metabolite (3‐bromocinnamamide, BC) was the main focus. Eight alumina‐gel monkeys were given by gastric bolus every 6 hr for 10… Expand
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