Short‐term effects of alcohol‐based disinfectant and detergent on skin irritation

  title={Short‐term effects of alcohol‐based disinfectant and detergent on skin irritation},
  author={Line Kynemund Pedersen and Elisabeth Held and Jeanne Duus Johansen and Tove Agner},
  journal={Contact Dermatitis},
The most important risk factor for occupational contact dermatitis in hospital personnel is the exposure to irritants such as water, detergents and alcohol‐based solutions. This study was undertaken to evaluate the short‐term effects of repeated exposure to an alcohol‐based disinfectant, to a detergent and to an alcohol‐based disinfectant/detergent alternately. The hardening effect in preirritated skin after a 4‐week interval was also evaluated. Detergent, disinfectant and disinfectant… 
Effects of disinfectants and detergents on skin irritation
The study shows that there is no summation of irritating effects of a common detergent and propanol and that the combination of washing and disinfection has a rather protective aspect compared with washing alone.
Skin condition associated with intensive use of alcoholic gels for hand disinfection: a combination of biophysical and sensorial data
From this study, it was concluded that gels containing an elevated glycerine concentration and 70% (v/v) ethanol are preferred, compared with other alcohol‐based disinfecting gels, which had less appreciation for isopropanol.
Emollients in a propanol‐based hand rub can significantly decrease irritant contact dermatitis
It is concluded that the addition of emollients to a propanol‐based hand rub can significantly decrease irritant contact dermatitis under frequent‐use conditions.
Causes of irritant contact dermatitis after occupational skin exposure: a systematic review
Strong evidence for an association between ICD and a combination of exposure to wet work and non-alcoholic disinfectants, moderate for metalworking fluids, limited for mechanical and glove exposure, and a strong evidence for a poor prognosis of ICD are reported.
Skin protection creams in medical settings: successful or evil?
Significant differences in efficacy were obtained between the two assayed skin protection creams, and contrasted effects of the creams corresponding to either a protective or an irritant effect on human stratum corneum were shown.
Skin barrier response to active chlorine hand disinfectant—An experimental study comparing skin barrier response to active chlorine hand disinfectant and alcohol‐based hand rub on healthy skin and eczematous skin
Alcohol‐based hand rub (ABHR) is widely used for hand disinfection in the health care sector. ABHR is, however, known to cause discomfort when applied on damaged skin emphasizing the unmet need for
Regional variability in stratum corneum reactivity to antiseptic formulations
Data show that PVP‐I 100 mg/ml was the least reactive antiseptic to the SC, which was significantly milder than the 2 other antiseptics.
Skin exposure in geriatric care – a comparison between observation and self‐assessment of exposure
The observations in this study suggest that nursing work in geriatric care may comprise limited exposure to water, and considers the questionnaire to be useful for surveying skin exposure in nursing.
The alcohol hand rub: a good soap substitute?
Short-chain aliphatic alcohols, ‘alcohol-based hand rubs’ (AHRs) are now in general use by healthcare professionals for hand disinfection in order to prevent transmission of pathogens and have been shown to contribute significantly to decreased infection rates.
Occupational Contact Dermatitis: Health Personnel
This chapter reviews the causes of occupational contact dermatitis and urticaria in nurses, clinical assistants and cleaners, surgeons, laboratory personnel, other therapist, veterinarians and laboratory animal handlers.


Experimental irritant contact dermatitis due to cumulative epicutaneous exposure to sodium lauryl sulphate and toluene: single and concurrent application
The results demonstrate that a mixed application of an anionic detergent and an organic solvent has an additive effect on skin irritation, and it is suggested that pretreatment with SLS causes an increased susceptibility to TOL irritation and vice versa.
Skin tolerance and effectiveness of two hand decontamination procedures in everyday hospital use
In everyday hospital practice, alcohol‐based disinfectant is more effective and better tolerated than non‐antiseptic soap; soap is at risk of spreading contamination; and skin comfort strongly influences the number and the quality of hand hygiene procedures.
The irritation potential and reservoir effect of mild soaps
Large differences in irritation potential are illustrated between 8 products and some of them demonstrated considerable damaging effect, and the study proved the presence of barrier‐impairing residues on the skin after rinsing with water.
Skin irritant reactivity following experimental cumulative irritant contact dermatitis
It is indicated that epidermal barrier function remains altered even 9 weeks after cumulative irritant contact dermatitis, and post‐irritation hyporeactivity might be a cause of false‐negative tests on previously irritated sites.
Occupational hand dermatitis in hospital environments
Assessment of the prevalence and clinical relevance of contact dermatitis in employees of the Perugia Monteluce Hospital found atopy seemed to favour the onset of hand dermatitis, and the importance of these results for preventive measures of contact Dermatitis in hospital employees is discussed.
The Role of Skin Moisturizers in the Prevention of Irritant Contact Dermatitis – A Review
  • C. Goh
  • Medicine
    Exogenous Dermatology
  • 2002
There has been sufficient evidence to suggest that moisturizers can prevent irritant contact dermatitis and should be recommended to workers who are constantly exposed to contact irritants.
Tandem application of sodium lauryl sulfate and n-propanol does not lead to enhancement of cumulative skin irritation.
N-propanol did not enhance cumulative skin irritation when used with sodium lauryl sulfate, as has been reported for toluene, and this is of particular interest regarding occupational skin irritation in health care workers.
Skin Irritation and Dryness Associated With Two Hand-Hygiene Regimens: Soap-and-Water Hand Washing Versus Hand Antisepsis With an Alcoholic Hand Gel
Hand antisepsis with an alcoholic–hand-gel regimen was well tolerated and did not result in skin irritation and dryness of nurses' hands, and newer alcoholic hand gels that are tolerated better than soap may be more acceptable to staff and may lead to improved hand-hygiene practices.
Does hand care ruin hand disinfection?
  • P. Heeg
  • Medicine
    The Journal of hospital infection
  • 2001