Short‐term calorie restriction ameliorates genomewide, age‐related alterations in DNA methylation

@inproceedings{Kim2016ShorttermCR,
  title={Short‐term calorie restriction ameliorates genomewide, age‐related alterations in DNA methylation},
  author={Cheol Hong Kim and Eun Kyeong Lee and Yeon Ja Choi and Hye Jin An and Hyeong Oh Jeong and Daeui Park and Byoung Chul Kim and Byung Pal Yu and Jong Bhak and Hae Yung Chung},
  booktitle={Aging cell},
  year={2016}
}
DNA methylation plays major roles in many biological processes, including aging, carcinogenesis, and development. Analyses of DNA methylation using next-generation sequencing offer a new way to profile and compare methylomes across the genome in the context of aging. We explored genomewide DNA methylation and the effects of short-term calorie restriction (CR) on the methylome of aged rat kidney. Whole-genome methylation of kidney in young (6 months old), old (25 months old), and OCR (old with 4… CONTINUE READING
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