Short‐Term Therapeutic Effects of Ozone in the Management of Pain in Knee Osteoarthritis: A Meta‐Analysis

@article{AriasVzquez2019ShortTermTE,
  title={Short‐Term Therapeutic Effects of Ozone in the Management of Pain in Knee Osteoarthritis: A Meta‐Analysis},
  author={Pedro Iv{\'a}n Arias-V{\'a}zquez and Carlos Alfonso Tovilla-Z{\'a}rate and Yazm{\'i}n Hern{\'a}ndez-D{\'i}az and Thelma Beatr{\'i}z Gonz{\'a}lez-Castro and Isela Esther Ju{\'a}rez-Rojop and Mar{\'i}a Lilia L{\'o}pez-Narv{\'a}ez and Deysi Yadira Berm{\'u}dez-Oca{\~n}a and Hugo Adri{\'a}n Barjau-Madrigal and Gabriela Legorreta-Ram{\'i}rez},
  journal={PM\&R},
  year={2019},
  volume={11}
}
Ozone therapy has been used widely to decrease pain related to osteoarthritis, but the effectiveness of this treatment has not been evaluated. 
Comparison of Non-NSAID Pain Management in the Treatment of Patients with Symptomatic Knee Osteoarthritis
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The efficacy of other modalities and interventions versus standard first-line therapy of nonsteroidal anti-inflammatory drugs for pain management in patients with symptomatic knee osteoarthritis is compared.
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The degree of evidence from such studies is so low that ozone should not be recommended for the treatment of KOA, and better designed studies are needed with a greater degree ofEvidence and with a longer follow-up to confirm what current literature reflects: that intraarticular ozone seems to be highlighted pain in the short-term in patients with KOA.
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In conclusion, the intra-articular viscosupplementation alone or associated with ozone gas allowed improvement of lameness scores and orthopedic examination score and the association of ozone gas had better results on kinetic analysis.
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American Medical Society for Sports Medicine Position Statement: Principles for the Responsible Use of Regenerative Medicine in Sports Medicine
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The comparison effects of intra-articular injection of Platelet Rich Plasma (PRP), Plasma Rich in Growth Factor (PRGF), Hyaluronic Acid (HA), and ozone in knee osteoarthritis; a one year randomized clinical trial
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Ozone injection had rapid effects and better short-term results after 2 months, but its therapeutic effects did not persist after 6’months and at the 6-month follow up, PRP,PRGF and HA were superior to ozone.
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References

SHOWING 1-10 OF 43 REFERENCES
American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee
To update the American College of Rheumatology (ACR) 2000 recommendations for hip and knee osteoarthritis (OA) and develop new recommendations for hand OA.
Osteoarthritis of the knee and hip. Part I: aetiology and pathogenesis as a basis for pharmacotherapy
TLDR
To obtain insight into the extent of pathological changes in hip and knee OA, current literature on the pathogenesis of this state is reviewed as a basis for current pharmacotherapy options.
Application of Ozone Therapy in Patients with Knee Osteoarthritis
TLDR
Evaluated ozone therapy in oxidative stress parameters in synovial fluid of patients suffering of knee osteoarthritis produced an intra-articular redox balance and a significant reduction of pain.
The role of ozone therapy in maintaining the articular function and in relieving the pain for patients with knee osteoarthritis
TLDR
Ozone Therapy is thought to be a non-pharmacological therapy, which makes use of oxygen and ozone, based on the ozone characteristics, such as the antibacterial and antimycotic, anti-inflammatory and immunomodulatory, for the optimization of the way the organs and systems function, but also of tissue bionourishing.
The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials
TLDR
Intra-articular PRP injections probably are more efficacious in the treatment of knee OA in terms of pain relief and self-reported function improvement at 3, 6 and 12 months follow-up, compared with other injections, including saline placebo, HA, ozone, and corticosteroids.
Safety of Intra-Articular Oxygen-Ozone Therapy Compared to Intra-ArticularSodium Hyaluronate in Knee Osteoarthritis: A Randomized Single Blind PilotStudy
TLDR
Despite IA administration of O2O3 and hyaluronan are comparable treatments in knee OA both in terms of safety and quality of life improvement, the latter shows longer times of pain reduction.
Comparative Efficacy of Intraarticular Injection of Combination of Ozone and Steroid and Ozone alone in Patients with Primary Knee Osteoarthritis: A Prospective and Randomized Clinical Analysis
TLDR
Ozone treatment was highly effective in relieving pain and improving functional outcome in patients with primary knee OA as well as in patients treated with single intraarticular injection of either ozone alone or combination of ozone with steroid.
Effect of Intraarticular injection of ozone on inflammatory cytokines in knee osteoarthritis
TLDR
Intraarticular Ozone induces significantly longer improvement of pain and disability in knee osteoartherosis compare to steroid injection, and serum inflammatory cytokines are also lower in Ozone group compared to steroid group along with clinical improvements.
Intra-articular ozone or hyaluronic acid injection: Which one is superior in patients with knee osteoarthritis? A 6-month randomized clinical trial
TLDR
Although both ozone and HA can be effectively used for improving function and reducing pain in selected knee OA patients, neither of the two showed any superiority at 6-month follow-up.
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