Short‐ and long‐term outcomes of metformin compared with insulin alone in pregnancy: a systematic review and meta‐analysis

@article{Butalia2017ShortAL,
  title={Short‐ and long‐term outcomes of metformin compared with insulin alone in pregnancy: a systematic review and meta‐analysis},
  author={Sonia Butalia and L Gutierrez and Abhay Lodha and E Aitken and A Zakariasen and Lois E. Donovan},
  journal={Diabetic Medicine},
  year={2017},
  volume={34},
  pages={27 - 36}
}
AIM To assess the short- and long-term maternal and fetal impact of metformin in pregnancy compared with insulin. [...] Key MethodMETHODS We performed a comprehensive literature search of MEDLINE, EMBASE, BIOSIS, Cochrane Database of Systematic Reviews and ClinicalTrials.gov.Expand
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Metformin treatment in pregnant women with polycystic ovary syndrome—is reduced complication rate mediated by changes in the uteroplacental circulation?
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To study a possible effect of metformin on the uteroplacental circulation, a large number of animals were slaughtered to study the effects of the drug on the uterus. Expand
Metformin vs. insulin in gestational diabetes. A randomized study characterizing metformin patients needing additional insulin
We compared metformin with insulin as treatment of gestational diabetes mellitus (GDM). Furthermore, we aimed to characterize metformin‐treated patients needing additional insulin to achieveExpand
Metformin should be considered in the treatment of gestational diabetes: a prospective randomised study
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The use of metformin in the treatment of gestational diabetes should be considered, according to a prospective randomised study carried out in Finland. Expand
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A meta-analysis of 5 RCTs comparing the effects of metformin with insulin on glycemic control, maternal and neonatal outcomes in gestational diabetes mellitus (GDM) found that it might be more suitable for women with mild GDM. Expand
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Effect comparison of metformin with insulin treatment for gestational diabetes: a meta-analysis based on RCTs
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Metformin can significantly reduce several adverse maternal and neonatal outcomes including PIH rate, incidence of hypoglycemia and NICU, thus it may be an effective and safe alternative or additional treatment to insulin for GDM women. Expand
Metformin's Effect on First-Year Weight Gain: A Follow-up Study
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Women randomized to metformin were heavier in the first trimester, gained less weight in pregnancy, and lost less weightIn the first year postpartum compared with women randomized to placebo, children exposed to met formin weighed more at 1 year of age. Expand
Growth, body composition and metabolic profile of 8-year-old children exposed to metformin in utero
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Metformin exposure during fetal life does not seem to influence growth and body composition at the age of 8 years, and a higher fasting glucose level and a possible higher systolic blood pressure and lower LDL cholesterol level in the metformin group may be coincidental. Expand
Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: a randomized, controlled multicenter study.
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Metformin treatment from first trimester to delivery did not reduce pregnancy complications in PCOS and women in the metformin group gained less weight during pregnancy compared with those in the placebo group. Expand
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