Short, full-dose adjuvant chemotherapy (CT) in high-risk adult soft tissue sarcomas (STS): long-term follow-up of a randomized clinical trial from the Italian Sarcoma Group and the Spanish Sarcoma Group.

@article{Gronchi2016ShortFA,
  title={Short, full-dose adjuvant chemotherapy (CT) in high-risk adult soft tissue sarcomas (STS): long-term follow-up of a randomized clinical trial from the Italian Sarcoma Group and the Spanish Sarcoma Group.},
  author={Alessandro Gronchi and Silvia Stacchiotti and Paolo Verderio and Stefano Ferrari and Javier Mart{\'i}n Broto and Antonio L{\'o}pez-pousa and Antonio Llombart-Bosch and Angelo P Dei Tos and Paola Collini and Josefina Cruz Jurado and Angela De Paoli and Davide Maria Donati and Andr{\'e}s M Poveda and Vittorio Quagliuolo and Alessandro Comandone and Giovanni Grignani and Carlo Morosi and Antonella Messina and Rita De Sanctis and Stefano Bottelli and Elena Palassini and Paolo Giovanni Casali and Piero Picci},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2016},
  volume={27 12},
  pages={2283-2288}
}
BACKGROUND To report on long-term results of a phase 3 trial comparing three versus five cycles of adjuvant chemotherapy (CT) with full-dose epirubicin+ifosfamide in high-risk soft tissue sarcomas (STS). METHODS Patients (pts) were randomized to receive three preoperative cycles of epirubicin 120 mg/m2 and ifosfamide 9 g/m2 (Arm A) or to receive the same three preoperative cycles plus two postoperative cycles (Arm B). Radiotherapy could be either delivered in the preoperative or in the… CONTINUE READING
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