Shockwaves induce osteogenic differentiation of human mesenchymal stem cells through ATP release and activation of P2X7 receptors.

@article{Sun2013ShockwavesIO,
  title={Shockwaves induce osteogenic differentiation of human mesenchymal stem cells through ATP release and activation of P2X7 receptors.},
  author={Dahui Sun and Wolfgang G. Junger and Changji Yuan and Wenyan Zhang and Yi Bao and Daming Qin and Chengxue Wang and Lei Tan and Baochang Qi and Dong Qing Zhu and Xizheng Zhang and Tiecheng Yu},
  journal={Stem cells},
  year={2013},
  volume={31 6},
  pages={1170-80}
}
Shockwave treatment promotes bone healing of nonunion fractures. In this study, we investigated whether this effect could be due to adenosine 5'-triphosphate (ATP) release-induced differentiation of human mesenchymal stem cells (hMSCs) into osteoprogenitor cells. Cultured bone marrow-derived hMSCs were subjected to shockwave treatment and ATP release was assessed. Osteogenic differentiation and mineralization of hMSCs were evaluated by examining alkaline phosphatase activity, osteocalcin… CONTINUE READING
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