Shocking HIV out of hiding: where are we with clinical trials of latency reversing agents?

  title={Shocking HIV out of hiding: where are we with clinical trials of latency reversing agents?},
  author={T. Rasmussen and S. Lewin},
  journal={Current Opinion in HIV and AIDS},
  • T. Rasmussen, S. Lewin
  • Published 2016
  • Medicine
  • Current Opinion in HIV and AIDS
  • Purpose of reviewTo provide an overview of the initial experiences with the use of latency-reversing agents (LRAs) in clinical trials in HIV and to discuss and contrast results arising from these studies. Recent findingsAlthough the clinical administration of histone deacetylase inhibitors (HDACis) and disulfiram to HIV-infected individuals on antiretroviral therapy significantly increased cell-associated HIV RNA in CD4+ T cells and in some cases plasma HIV RNA, this did not reduce the… CONTINUE READING
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