Shock wave induced sonoporation and gene transfer

  title={Shock wave induced sonoporation and gene transfer},
  author={Douglas L. Miller},
During shockwave (SW) treatment, cavitation activity can be applied for cell killing. A bonus is that some surviving cells appear to be briefly permeabilized, or sonoporated, allowing them to take up large molecules including DNA. In vitro research has indicated that as the number of SW increased, survival declined exponentially but the number of sonoporated cells increased to better than 50% of survivors for 1000 SW. In vivo tests have demonstrated SW‐induced tumor ablation could indeed be… CONTINUE READING

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