Shock priming enhances the efficacy of SSRIs in the foot shock-induced ultrasonic vocalization test.

@article{Kassai2012ShockPE,
  title={Shock priming enhances the efficacy of SSRIs in the foot shock-induced ultrasonic vocalization test.},
  author={Ferenc Kassai and Istv{\'a}n Gyerty{\'a}n},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2012},
  volume={36 1},
  pages={128-35}
}
Data on the effect of acutely administered serotonin reuptake inhibitors (SSRIs) in animal anxiety models have been inconsistent. In some of the models these compounds showed anxiolytic properties, while in others they were ineffective or even anxiogenic. In the foot shock-induced ultrasonic vocalization (USV) test in the adult rat, SSRIs were reported to be effective, however, they were only tested with protocols using multiple shocking design. In the present study, anxiolytic effects of… CONTINUE READING
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