Shizukaol D, a Dimeric Sesquiterpene Isolated from Chloranthus serratus, Represses the Growth of Human Liver Cancer Cells by Modulating Wnt Signalling Pathway.

@article{Tang2016ShizukaolDA,
  title={Shizukaol D, a Dimeric Sesquiterpene Isolated from Chloranthus serratus, Represses the Growth of Human Liver Cancer Cells by Modulating Wnt Signalling Pathway.},
  author={LiSha Tang and Hengrui Zhu and Xianmei Yang and Fang Xie and Jingtao Peng and Deke Jiang and Jun Xie and Meiyan Qi and Long Yu},
  journal={PloS one},
  year={2016},
  volume={11 3},
  pages={e0152012}
}
Natural products have become sources of developing new drugs for the treatment of cancer. To seek candidate compounds that inhibit the growth of liver cancer, components of Chloranthus serratus were tested. Here, we report that shizukaol D, a dimeric sesquiterpene from Chloranthus serratus, exerted a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner. We demonstrated that shizukaol D induced cells to undergo apoptosis. More importantly, shizukaol D attenuated… CONTINUE READING