Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity

@inproceedings{Klaassen2016Shisa6TA,
  title={Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity},
  author={Remco V. Klaassen and Jasper Stroeder and Françoise Coussen and Anne-Sophie Hafner and Jennifer D. Petersen and Cedric Renancio and Leanne J. M. Schmitz and Elisabeth Normand and Johannes C. Lodder and Diana C Rotaru and Priyanka Rao-Ruiz and Sabine Spijker and Huibert D. Mansvelder and Daniel Choquet and August B. Smit},
  booktitle={Nature communications},
  year={2016}
}
Trafficking and biophysical properties of AMPA receptors (AMPARs) in the brain depend on interactions with associated proteins. We identify Shisa6, a single transmembrane protein, as a stable and directly interacting bona fide AMPAR auxiliary subunit. Shisa6 is enriched at hippocampal postsynaptic membranes and co-localizes with AMPARs. The Shisa6 C-terminus harbours a PDZ domain ligand that binds to PSD-95, constraining mobility of AMPARs in the plasma membrane and confining them to… CONTINUE READING
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