Shikonin protects H9C2 cardiomyocytes against hypoxia/reoxygenation injury through activation of PI3K/Akt signaling pathway.

@article{Wang2018ShikoninPH,
  title={Shikonin protects H9C2 cardiomyocytes against hypoxia/reoxygenation injury through activation of PI3K/Akt signaling pathway.},
  author={Shuang Wang and Yanfang Zhu and Ruixia Qiu},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2018},
  volume={104},
  pages={
          712-717
        }
}
Myocardial ischemic/reperfusion (I/R) injury often leads to irreversible myocardial cell death and even heart failure, with limited therapeutic possibilities. In the present study, we evaluated the protective effects of shikonin (SHK) against hypoxia/reoxygenation (H/R)-induced cardiomyocyte damage and explored the underlying mechanisms. H9C2 cardiomyocytes… CONTINUE READING