Shikonin inhibits adipogenesis by modulation of the WNT/β-catenin pathway.

@article{Lee2011ShikoninIA,
  title={Shikonin inhibits adipogenesis by modulation of the WNT/β-catenin pathway.},
  author={Haeyong Lee and Sungmin Bae and Kijeong Kim and Wonyong Kim and Sang-in Chung and Young Yang and Yoosik Yoon},
  journal={Life sciences},
  year={2011},
  volume={88 7-8},
  pages={294-301}
}
AIM Our previous study showed for the first time that shikonin, a natural compound isolated from Lithospermun erythrorhizon Sieb. Et Zucc, inhibits adipogenesis and fat accumulation. This study was conducted to investigate the molecular mechanism of the anti-adipogenic effects of shikonin. MAIN METHODS Gene knockdown experiments using small interfering RNA (siRNA) transfection were conducted to elucidate the crucial role of β-catenin in the anti-adipogenic effects of shikonin. KEY FINDINGS… CONTINUE READING

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