Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine

@article{Chen2012ShikoninII,
  title={Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine},
  author={Hui-ming Chen and Pi-Hsueh Wang and S A Chen and Chih-Chun Wen and Yun-Hsiang Chen and Wen-Chin Yang and N. T. Yang},
  journal={Cancer Immunology, Immunotherapy},
  year={2012},
  volume={61},
  pages={1989-2002}
}
Immunogenic cell death is characterized by damage-associated molecular patterns, which can enhance the maturation and antigen uptake of dendritic cells. Shikonin, an anti-inflammatory and antitumor phytochemical, was exploited here as an adjuvant for dendritic cell-based cancer vaccines via induction of immunogenic cell death. Shikonin can effectively activate both receptor- and mitochondria-mediated apoptosis and increase the expression of all five tested damage-associated molecular patterns… CONTINUE READING
Highly Cited
This paper has 42 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
27 Citations
57 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 57 references

Similar Papers

Loading similar papers…