Shikonin exerts anti-inflammatory effects in a murine model of lipopolysaccharide-induced acute lung injury by inhibiting the nuclear factor-kappaB signaling pathway.

@article{Liang2013ShikoninEA,
  title={Shikonin exerts anti-inflammatory effects in a murine model of lipopolysaccharide-induced acute lung injury by inhibiting the nuclear factor-kappaB signaling pathway.},
  author={Dejie Liang and Yong Sun and Yongbin Shen and Fengyang Li and Xiaojing Song and Ershun Zhou and Fuyi Zhao and Z. W. Liu and Yunhe Fu and Mengyao Guo and Nai-sheng Zhang and Zhengtao Yang and Yongguo Cao},
  journal={International immunopharmacology},
  year={2013},
  volume={16 4},
  pages={475-80}
}
Shikonin, an analog of naphthoquinone pigments isolated from the root of Lithospermum erythrorhyzon, was recently reported to exert beneficial anti-inflammatory effects both in vivo and in vitro. The present study aimed to investigate the potential therapeutic effect of shikonin in a murine model of lipopolysaccharide (LPS)-induced acute lung injury (ALI). Dexamethasone was used as a positive control to evaluate the anti-inflammatory effect of shikonin in the study. Pretreatment with shikonin… CONTINUE READING
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