Shikonin and its derivatives: a patent review.

  title={Shikonin and its derivatives: a patent review.},
  author={Rubing Wang and Runting Yin and Wen Zhou and Defeng Xu and Shao-shun Li},
  journal={Expert opinion on therapeutic patents},
  volume={22 9},
INTRODUCTION Shikonin and its derivatives are the main components of red pigment extracts from Lithospermum erythrorhizon, whose medicinal properties have been confirmed for a long history, and have aroused great interest as the hallmark molecules responsible for their significant biological activities, especially for their striking anticancer effects. AREAS COVERED Areas covered in this paper include a review of the total synthesis, biological effects and mechanisms of shikonin and its… CONTINUE READING