Shikonin Kills Glioma Cells through Necroptosis Mediated by RIP-1


BACKGROUND AND PURPOSE Shikonin was reported to induce necroptosis in leukemia cells, but apoptosis in glioma cell lines. Thus, it is needed to clarify whether shikonin could cause necroptosis in glioma cells and investigate its underlying mechanisms. METHODS Shikonin and rat C6 glioma cell line and Human U87 glioma cell line were used in this study. The… (More)
DOI: 10.1371/journal.pone.0066326


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