Shikonin, a component of antiinflammatory Chinese herbal medicine, selectively blocks chemokine binding to CC chemokine receptor-1.

@article{Chen2001ShikoninAC,
  title={Shikonin, a component of antiinflammatory Chinese herbal medicine, selectively blocks chemokine binding to CC chemokine receptor-1.},
  author={Xin Chen and Joost J Oppenheim and Ola Mae Zack Howard},
  journal={International immunopharmacology},
  year={2001},
  volume={1 2},
  pages={229-36}
}
Shikonin is a chemically characterized component of traditional Chinese herbal medicine and has been shown to possess antiinflammatory activities. We ascertained that shikonin blocked radiolabelled Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) and macrophage inflammatory protein-1 (MIP-1alpha) binding to human monocytes with IC50… CONTINUE READING