Shiga toxins stimulate secretion of interleukin-8 from intestinal epithelial cells.

  title={Shiga toxins stimulate secretion of interleukin-8 from intestinal epithelial cells.},
  author={Cheleste M Thorpe and Bryan P Hurley and L L Lincicome and Mary S Jacewicz and Gerald T Keusch and David W. K. Acheson},
  journal={Infection and immunity},
  volume={67 11},
In the 1980s, Shiga toxin (Stx)-producing Escherichia coli O157:H7 (STEC) was identified as a cause of hemorrhagic colitis in the United States and was found to be associated with hemolytic uremic syndrome (HUS), a microangiopathic hemolytic anemia characterized by thrombocytopenia and renal failure. The precise way that Stxs cause hemorrhagic colitis and HUS is unclear. Stxs have been thought to cause disease by killing or irreversibly harming sensitive cells through a nonspecific blockade of… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
75 Citations
38 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 75 extracted citations


Publications referenced by this paper.
Showing 1-10 of 38 references

Epithelial cell responses to Shiga toxin-producing Escherichia coli infection, p. 213–225

  • A. Ismaili, D. J. Philpott, D. M. McKay, M. H. Perdue, P. M. Sherman
  • 1998

Similar Papers

Loading similar papers…