Shiga toxins induce autophagy leading to differential signalling pathways in toxin-sensitive and toxin-resistant human cells.

@article{Lee2011ShigaTI,
  title={Shiga toxins induce autophagy leading to differential signalling pathways in toxin-sensitive and toxin-resistant human cells.},
  author={Moo-Seung Lee and Rama P. Cherla and Matthew H Jenson and Dinorah Leyva-Illades and Margarita Martinez-Moczygemba and Vernon L. Tesh},
  journal={Cellular microbiology},
  year={2011},
  volume={13 10},
  pages={1479-96}
}
The bacterial virulence factors Shiga toxins (Stxs) are expressed by Shigella dysenteriae serotype 1 and certain Escherichia coli strains. Stxs are protein synthesis inhibitors and induce apoptosis in many cell types. Stxs induce apoptosis via prolonged endoplasmic reticulum stress signalling to activate both extrinsic and intrinsic pathways in human myeloid cells. Studies have shown that autophagy, a lysosome-dependent catabolic process, may be associated with activation of pro-survival or… CONTINUE READING

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