Shiga toxins 1 and 2 translocate differently across polarized intestinal epithelial cells.

@article{Hurley1999ShigaT1,
  title={Shiga toxins 1 and 2 translocate differently across polarized intestinal epithelial cells.},
  author={Bryan P Hurley and Mary S Jacewicz and Cheleste M Thorpe and L L Lincicome and Audrey J. King and Gerald T Keusch and David W. K. Acheson},
  journal={Infection and immunity},
  year={1999},
  volume={67 12},
  pages={6670-7}
}
Shiga toxin-producing Escherichia coli (STEC) is an important food-borne pathogen that causes hemolytic-uremic syndrome. Following ingestion, STEC cells colonize the intestine and produce Shiga toxins (Stx), which appear to translocate across the intestinal epithelium and subsequently reach sensitive endothelial cell beds. STEC cells produce one or both of two major toxins, Stx1 and Stx2. Stx2-producing STEC is more often associated with disease for reasons as yet undetermined. In this study… CONTINUE READING