Shiga toxins: from structure and mechanism to applications

  title={Shiga toxins: from structure and mechanism to applications},
  author={Yau Sang Chan and T. B. Ng},
  journal={Applied Microbiology and Biotechnology},
Shiga toxins are a group of type 2 ribosome-inactivating proteins (RIPs) produced in several types of bacteria. The toxins possess an AB5 structure, which comprises a catalytic A chain with N-glycosidase activity, and five identical B chains and recognize and bind to the target cells with specific carbohydrate moieties. In humans, the major molecular target which recognizes the Shiga toxins is the Gb3 receptor, which is mainly expressed on the cell surface of endothelial cells of the intestine… CONTINUE READING
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