Shiga toxin-mediated disease in MyD88-deficient mice infected with Escherichia coli O157:H7.

@article{Toledo2008ShigaTD,
  title={Shiga toxin-mediated disease in MyD88-deficient mice infected with Escherichia coli O157:H7.},
  author={Carla Calderon Toledo and Trisha Jayne Rogers and Majlis Svensson and Ramesh Tati and Hans Fischer and Catharina Svanborg and Diana Karpman},
  journal={The American journal of pathology},
  year={2008},
  volume={173 5},
  pages={
          1428-39
        }
}
Toll-like receptors (TLRs) are key factors of innate immunity that detect pathogen invasion and trigger a host response. TLR4 can mediate a response through adaptor molecules, MyD88 or TRIF. In the present study, streptomycin-treated MyD88(-/-), Tlr4(-/-), Trif (Lps2/Lps2), and C57BL/6 wild-type (WT) mice were infected with either Shiga toxin (Stx)-producing or non-producing Escherichia coli O157:H7. Moderate to severe clinical signs of disease developed in MyD88(-/-) (n = 21/21), Tlr4(-/-) (n… CONTINUE READING
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