Shiga toxin-associated hemolytic uremic syndrome: pathophysiology of endothelial dysfunction

@article{Zoja2010ShigaTH,
  title={Shiga toxin-associated hemolytic uremic syndrome: pathophysiology of endothelial dysfunction},
  author={C. Zoja and S. Buelli and M. Morigi},
  journal={Pediatric Nephrology},
  year={2010},
  volume={25},
  pages={2231-2240}
}
Shiga toxin (Stx)-producing enterohemorrhagic Escherichia coli O157:H7 has become a global threat to public health, as a primary cause of a worldwide spread of hemorrhagic colitis complicated by diarrhea-associated hemolytic uremic syndrome (HUS), a disorder of thrombocytopenia, microangiopathic hemolytic anemia, and acute renal failure that mainly affects early childhood. Endothelial dysfunction has been recognized as the trigger event in the development of microangiopathic processes… Expand
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