Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands

@article{Kitov2000ShigalikeTA,
  title={Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands},
  author={Pavel I. Kitov and Joanna M. Sadowska and George Mulvey and Glen D. Armstrong and Hong Ling and Navraj S. Pannu and Randy J Read and David R Bundle},
  journal={Nature},
  year={2000},
  volume={403},
  pages={669-672}
}
The diseases caused by Shiga and cholera toxins account for the loss of millions of lives each year. Both belong to the clinically significant subset of bacterial AB5 toxins consisting of an enzymatically active A subunit that gains entry to susceptible mammalian cells after oligosaccharide recognition by the B5 homopentamer. Therapies might target the obligatory oligosaccharide–toxin recognition event, but the low intrinsic affinity of carbohydrate–protein interactions hampers the development… CONTINUE READING