Shiga-like toxins and HIV-1 'go through' glycosphingolipids and lipid rafts in renal cells.

Abstract

The binding of Shiga-like toxins (Stx) to globotriaosyl ceramide (Gb(3)) in renal cells plays a central role in Stx-induced hemolytic uremic syndrome (Stx-HUS). Khan et al. show that the presence of Gb(3) within lipid raft microdomains in glomerular but not tubular cells may be the basis for the glomerular- and age-restricted pathology of Stx-HUS. They also… (More)
DOI: 10.1038/ki.2009.72

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