Shifting the equilibrium between the encounter state and the specific form of a protein complex by interfacial point mutations.

@article{Volkov2010ShiftingTE,
  title={Shifting the equilibrium between the encounter state and the specific form of a protein complex by interfacial point mutations.},
  author={Alexander N. Volkov and Qamar Bashir and Jonathan A R Worrall and G. Matthias Ullmann and Marcellus Ubbink},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 33},
  pages={11487-95}
}
Recent experimental studies have confirmed a long-held view that protein complex formation proceeds via a short-lived encounter state. The population of this transient intermediate, stabilized mainly by long-range electrostatic interactions, varies among different complexes. Here we show that the occupancy of the encounter state can be modulated across a broad range by single point mutations of interfacial residues. Using a combination of Monte Carlo simulations and paramagnetic relaxation… CONTINUE READING
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