Shifting imaging targets in multiple sclerosis: from inflammation to neurodegeneration.

  title={Shifting imaging targets in multiple sclerosis: from inflammation to neurodegeneration.},
  author={Ren{\'e} M Vigeveno and O T Wiebenga and Mike P. Wattjes and J. J. G. Geurts and Frederik Barkhof},
  journal={Journal of magnetic resonance imaging : JMRI},
  volume={36 1},
Classically multiple sclerosis (MS) has been regarded as an auto-immune disease of the white matter in the central nervous system leading to severe disability over the course of several decades. Current therapeutic strategies in MS are mostly based on either immune suppression or immune modulation. Although effective in decreasing relapse frequency and severity as well as delaying disease progression, MS pathology ensues nonetheless. In the last decade it became evident that gray matter… CONTINUE READING


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