Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis.

@article{Puntambekar2011ShiftingHO,
  title={Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis.},
  author={Shweta S. Puntambekar and Cornelia C. Bergmann and Carine Savarin and Christopher L. Karp and Timothy W. Phares and Gabriel I. Parra and David R Hinton and Stephen A. Stohlman},
  journal={Journal of virology},
  year={2011},
  volume={85 13},
  pages={6702-13}
}
Interleukin-10 (IL-10) mRNA is rapidly upregulated in the central nervous system (CNS) following infection with neurotropic coronavirus and remains elevated during persistent infection. Infection of transgenic IL-10/green fluorescent protein (GFP) reporter mice revealed that CNS-infiltrating T cells were the major source of IL-10, with minimal IL-10 production by macrophages and resident microglia. The proportions of IL-10-producing cells were initially similar in CD8(+) and CD4(+) T cells but… CONTINUE READING

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