Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis.

@article{Mkaddem2014ShiftingFF,
  title={Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis.},
  author={Sanae Ben Mkaddem and Gilles Hayem and Friederike J{\"o}nsson and E. Rossato and Erwan Boedec and Tarek Boussetta and Jamel El Benna and Pierre Launay and J M Goujon and M. Benhamou and Pierre Bruhns and Renato D. C. Monteiro},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 9},
  pages={3945-59}
}
Rheumatoid arthritis-associated (RA-associated) inflammation is mediated through the interaction between RA IgG immune complexes and IgG Fc receptors on immune cells. Polymorphisms within the gene encoding the human IgG Fc receptor IIA (hFcγRIIA) are associated with an increased risk of developing RA. Within the hFcγRIIA intracytoplasmic domain, there are 2… CONTINUE READING