ShiftDetector: detection of shift mutations

  title={ShiftDetector: detection of shift mutations},
  author={Eyal Seroussi and Micha Ron and Darek Kedra},
  volume={18 8},
MOTIVATION Sequencing of a bi-allelic PCR product, which contains an allele with a deletion/insertion mutation results in a superimposed tracefile following the site of this shift mutation. A trace file of this type hampers the use of current computer programs for base calling. ShiftDetector analyses a sequencing trace file in order to discover if it is a superimposed sequence of two molecules that differ in a shift mutation of 1 to 25 bases. The program calculates a probability score for the… CONTINUE READING

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