Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis.

@article{Dolhain1996ShiftTT,
  title={Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis.},
  author={Radboud J.E.M Dolhain and A N van der Heiden and Natalja Tatjana ter Haar and Ferdinand C. Breedveld and Andr{\'e} M. M. Miltenburg},
  journal={Arthritis and rheumatism},
  year={1996},
  volume={39 12},
  pages={1961-9}
}
OBJECTIVE To investigate whether T cells in the inflamed joints of patients with rheumatoid arthritis (RA) preferentially produce the T helper 1 (Th1) cytokines, interferon-gamma (IFN gamma) and interleukin-2 (IL-2), or the Th2 cytokine, IL-4, when compared with corresponding peripheral blood-derived T cells. METHODS Synovial fluid mononuclear cells (SFMC) and corresponding peripheral blood mononuclear cells (PBMC) from 10 patients with RA were analyzed, either directly or after in vitro… CONTINUE READING

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