Shift of the cellular oxidation-reduction potential in neural cells expressing Bcl-2.

@article{Ellerby1996ShiftOT,
  title={Shift of the cellular oxidation-reduction potential in neural cells expressing Bcl-2.},
  author={Lisa M. Ellerby and H. Michael Ellerby and Sang Myun Park and Anne L. Holleran and Anne N Murphy and Gary Fiskum and D J Kane and Maria Pia Testa and Ceren Kayalar and Dale E. Bredesen},
  journal={Journal of neurochemistry},
  year={1996},
  volume={67 3},
  pages={1259-67}
}
Expression of the protooncogene bcl-2 inhibits both apoptotic and in some cases necrotic cell death in many cell types, including neural cells, and in response to a wide variety of inducers. The mechanism by which the Bcl-2 protein acts to prevent cell death remains elusive. One mechanism by which Bcl-2 has been proposed to act is by decreasing the net cellular generation of reactive oxygen species. To evaluate this proposal, we measured activities of antioxidant enzymes as well as levels of… CONTINUE READING

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