Shift of monocyte function toward cellular immunity during sleep.

@article{Lange2006ShiftOM,
  title={Shift of monocyte function toward cellular immunity during sleep.},
  author={Tanja Lange and Stoyan Dimitrov and Horst-Lorenz Fehm and J{\"u}rgen Westermann and Jan Born},
  journal={Archives of internal medicine},
  year={2006},
  volume={166 16},
  pages={1695-700}
}
BACKGROUND Sleep is considered to strengthen immune defense. We hypothesized that sleep achieves this effect by shifting the balance between types 1 and 2 cytokine activity toward increased type 1 activity, thereby supporting adaptive cellular immune responses. METHODS We analyzed monocyte-derived type 1 (interleukin 12 [IL-12]) and type 2 (IL-10) cytokines by means of multiparametric flow cytometry in healthy human subjects (n = 11) during a regular sleep-wake cycle and 24 hours of… CONTINUE READING
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