Shift of microRNA profile upon orthotopic xenografting of glioblastoma spheroid cultures

Abstract

Glioblastomas always recur despite surgery, radiotherapy and chemotherapy. A key player in the therapeutic resistance may be immature tumor cells with stem-like properties (TSCs) escaping conventional treatment. A group of promising molecular targets are microRNAs (miRs). miRs are small non-coding RNAs exerting post-transcriptional regulation of gene… (More)
DOI: 10.1007/s11060-016-2125-x

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