Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production.

@article{AbdollahiRoodsaz2008ShiftFT,
  title={Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production.},
  author={Shahla Abdollahi-Roodsaz and Leo A B Joosten and Monique M. A. Helsen and Birgitte Walgreen and Peter L. E. M. van Lent and Liduine A M van den Bersselaar and Marije I. Koenders and Wim B. van den Berg},
  journal={Arthritis and rheumatism},
  year={2008},
  volume={58 12},
  pages={3753-64}
}
OBJECTIVE Toll-like receptors (TLRs) may activate innate and adaptive immune responses in rheumatoid arthritis (RA) through recognition of microbial as well as endogenous ligands that have repeatedly been found in arthritic joints. The objective of this study was to investigate the involvement of TLR-2 and TLR-4 in the development of chronic destructive streptococcal cell wall (SCW)-induced arthritis, in which interleukin-1 (IL-1)/IL-17-dependent T cell-driven pathologic changes replace the… CONTINUE READING
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