Shift Work or Food Intake during the Rest Phase Promotes Metabolic Disruption and Desynchrony of Liver Genes in Male Rats

@inproceedings{SalgadoDelgado2013ShiftWO,
  title={Shift Work or Food Intake during the Rest Phase Promotes Metabolic Disruption and Desynchrony of Liver Genes in Male Rats},
  author={Roberto C Salgado-Delgado and Nadia Saderi and Mar{\'i}a Del Carmen Basualdo and Natali Nadia Guerrero-Vargas and Carolina Escobar and Ruud Marinus Buijs},
  booktitle={PloS one},
  year={2013}
}
In the liver, clock genes are proposed to drive metabolic rhythms. These gene rhythms are driven by the suprachiasmatic nucleus (SCN) mainly by food intake and via autonomic and hormonal pathways. Forced activity during the normal rest phase, induces also food intake, thus neglecting the signals of the SCN, leading to conflicting time signals to target tissues of the SCN. The present study explored in a rodent model of night-work the influence of food during the normal sleep period on the… CONTINUE READING
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