Shh signaling is essential for rugae morphogenesis in mice

@article{Lee2011ShhSI,
  title={Shh signaling is essential for rugae morphogenesis in mice},
  author={Jong‐Min Lee and Seita Miyazawa and Jeong-Oh Shin and Hyuk‐Jae Kwon and Dae-Woon Kang and Byung-Jai Choi and Jaeho Lee and Shigeru Kondo and Sung-Won Cho and Han-Sung Jung},
  journal={Histochemistry and Cell Biology},
  year={2011},
  volume={136},
  pages={663-675}
}
Palatal ridges, or rugae palatinae, are corrugated structures observed in the hard palate region. They are found in most mammalian species, but their number and arrangement are species-specific. Nine palatal rugae are found in the mouse secondary palate. Previous studies have shown that epithelial Shh signaling in the palatal ridge plays an important role during rugae development. Moreover, Wnt family members, including LEF1, play a functional role in orofacial morphogenesis. To explore the… Expand
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