Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks

@article{Fontana2018ShepherdingDE,
  title={Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks},
  author={Gabriele A Fontana and Julia K Reinert and Nicolas H. Thom{\"a} and Ulrich Rass},
  journal={Microbial Cell},
  year={2018},
  volume={5},
  pages={327 - 343}
}
Cells have evolved conserved mechanisms to protect DNA ends, such as those at the termini of linear chromosomes, or those at DNA double-strand breaks (DSBs). In eukaryotes, DNA ends at chromosomal termini are packaged into proteinaceous structures called telomeres. Telomeres protect chromosome ends from erosion, inadvertent activation of the cellular DNA damage response (DDR), and telomere fusion. In contrast, cells must respond to damage-induced DNA ends at DSBs by harnessing the DDR to… 

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