Sheep retrovirus structural protein induces lung tumours

@article{Wootton2005SheepRS,
  title={Sheep retrovirus structural protein induces lung tumours},
  author={Sarah K Wootton and Christine L. Halbert and A Dusty Miller},
  journal={Nature},
  year={2005},
  volume={434},
  pages={904-907}
}
Jaagsiekte sheep retrovirus (JSRV) causes a contagious lung cancer in sheep and goats, with significant animal health and economic consequences. The host range of JSRV is in part limited by species-specific differences in the virus entry receptor, hyaluronidase 2 (Hyal2), which is not functional as a receptor in mice but is functional in humans. Sheep are immunotolerant of JSRV because of the expression of closely related endogenous retroviruses, which are not present in humans and most other… CONTINUE READING

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