Sheep model for study of maternal adrenal gland function during pregnancy.

@article{KellerWood1998SheepMF,
  title={Sheep model for study of maternal adrenal gland function during pregnancy.},
  author={Maureen Keller-Wood and Timothy A. Cudd and Wendy Norman and Sylvia McGeary Caldwell and Charles E. Wood},
  journal={Laboratory animal science},
  year={1998},
  volume={48 5},
  pages={507-12}
}
Our goal was to develop a model for the study of maternal adrenal gland regulation and the effects of maternal cortisol secretion on fetal homeostasis. At about 108 days of gestation, before the time of rapid fetal growth or fetal adrenocortical maturation, ewes, under halothane anesthesia with controlled ventilation and positioned in sternal recumbency, were adrenalectomized. Ewes were treated with aldosterone by intravenous infusion (3 micrograms/kg of body weight per day) to induce normal… CONTINUE READING