Sheep cloned by nuclear transfer from a cultured cell line

@article{Campbell1996SheepCB,
  title={Sheep cloned by nuclear transfer from a cultured cell line},
  author={K. Campbell and J. Mcwhir and W. Ritchie and I. Wilmut},
  journal={Nature},
  year={1996},
  volume={380},
  pages={64-66}
}
  • K. Campbell, J. Mcwhir, +1 author I. Wilmut
  • Published 1996
  • Biology, Medicine
  • Nature
  • NUCLEAR transfer has been used in mammals as both a valuable tool in embryological studies1 and as a method for the multiplication of 'elite' embryos2–4. Offspring have only been reported when early embryos, or embryo-derived cells during primary culture, were used as nuclear donors5,6. Here we provide the first report, to our knowledge, of live mammalian offspring following nuclear transfer from an established cell line. Lambs were born after cells derived from sheep embryos, which had been… CONTINUE READING
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