Shedding of the endothelial glycocalyx during cardiac surgery: on-pump versus off-pump coronary artery bypass graft surgery.

@article{Bruegger2009SheddingOT,
  title={Shedding of the endothelial glycocalyx during cardiac surgery: on-pump versus off-pump coronary artery bypass graft surgery.},
  author={Dirk Bruegger and Markus Rehm and Jan M Abicht and Joern Oliver Paul and Mechthild Stoeckelhuber and Markus Pfirrmann and B. W. Carney G. N. Cecil C. R. Evans H. J. Karwowski Reichart and Bernhard Friedrich Becker and Frank Christ},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2009},
  volume={138 6},
  pages={1445-7}
}
A healthy vascular endothelium is coated by the endothelial glycocalyx. Its main constituents are transmembrane syndecans and bound heparan sulfates. In vivo the glycocalyx binds plasma proteins, forming the endothelial surface layer, which has a thickness of 500 to 1000 nm in microvessels. This large structure maintains the physiologic permeability barrier and prevents leukocyte and platelet adhesion, thereby mitigating inflammation and tissue edema. Very recently, we provided the first… CONTINUE READING