Shedding of mutant tumor necrosis factor receptor superfamily 1A associated with tumor necrosis factor receptor-associated periodic syndrome: differences between cell types.

@article{Huggins2004SheddingOM,
  title={Shedding of mutant tumor necrosis factor receptor superfamily 1A associated with tumor necrosis factor receptor-associated periodic syndrome: differences between cell types.},
  author={Mary L. Huggins and Paul M Radford and Richard S Mcintosh and Susan E Bainbridge and Peter Dickinson and Kelly-Ann Draper-Morgan and Patrick J Tighe and Richard James Powell and Ian Todd},
  journal={Arthritis and rheumatism},
  year={2004},
  volume={50 8},
  pages={2651-9}
}
OBJECTIVE To investigate the effect of mutations in tumor necrosis factor receptor superfamily 1A (TNFRSF1A) on the ability of the receptors to be cleaved from the cell surface upon stimulation. The mutations we studied are associated with clinically distinct forms of TNF receptor-associated periodic syndrome (TRAPS). We also investigated different cell types within the same form of TRAPS. METHODS The shedding of TNFRSF1A in response to stimulation with phorbol myristate acetate was assessed… CONTINUE READING

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