Shedding of membrane vesicles mediates fibroblast growth factor-2 release from cells.

@article{Taverna2003SheddingOM,
  title={Shedding of membrane vesicles mediates fibroblast growth factor-2 release from cells.},
  author={Simona Taverna and Giulio Ghersi and Angela Ginestra and Salvatrice Rigogliuso and Sonia Pecorella and Giovanna Alaimo and Francesca Saladino and Vincenza Dolo and Patrizia Dell'era and Antonio Pavan and Giuseppe Pizzolanti and Paolo Mignatti and Marco Presta and Maria Letizia Vittorelli},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 51},
  pages={51911-9}
}
Fibroblast growth factor-2 (FGF-2), a polypeptide with regulatory activity on cell growth and differentiation, lacks a conventional secretory signal sequence, and its mechanism of release from cells remains unclear. We characterized the role of extracellular vesicle shedding in FGF-2 release. Viable cells released membrane vesicles in the presence of serum. However, in serum-free medium vesicle shedding was dramatically down-regulated, and the cells did not release FGF-2 activity into their… CONTINUE READING
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