Shedding of endothelial protein C receptor contributes to vasculopathy and renal injury in lupus: in vivo and in vitro evidence.

@article{Sesin2005SheddingOE,
  title={Shedding of endothelial protein C receptor contributes to vasculopathy and renal injury in lupus: in vivo and in vitro evidence.},
  author={Carlos A Sesin and Xiaoming Yin and Charles T. Esmon and Jill P. Buyon and Robert M. Clancy},
  journal={Kidney international},
  year={2005},
  volume={68 1},
  pages={110-20}
}
BACKGROUND Candidate biomarkers for vasculopathy in systemic lupus erythematosus (SLE) include circulating endothelial cells and the recently identified endothelial protein C receptor (EPCR) which, when shed, promotes a thrombotic diathesis. This study sought correlation between plasma levels of soluble EPCR and disease manifestation/severity, with a focus on lupus nephritis. METHODS In 81 SLE patients (evaluated cross-sectionally and longitudinally) and 59 healthy controls, levels of soluble… CONTINUE READING
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