Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: heterogeneous involvement of the "a disintegrin and metalloproteases" 10 and 17.

@article{Chitadze2013SheddingOE,
  title={Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: heterogeneous involvement of the "a disintegrin and metalloproteases" 10 and 17.},
  author={Guranda Chitadze and Marcus Lettau and J Bhat and Daniela Wesch and Alexander Steinle and Daniel Fuerst and Joannis Mytilineos and Holger Kalthoff and Ottmar Janssen and Hans-Heinrich Oberg and Dieter Kabelitz},
  journal={International journal of cancer},
  year={2013},
  volume={133 7},
  pages={1557-66}
}
The interaction of the MHC class I-related chain molecules A and B (MICA and MICB) with the corresponding natural killer group 2, member D (NKG2D) receptor triggers cytotoxic effector activity of natural killer cells and certain T-cell subsets and provides a costimulatory signal for cytokine production. Thus, the presence of MICA/B on transformed cells contributes to tumor immunosurveillance. Consequently, the proteolytic cleavage of MICA/B is regarded as an important immune escape mechanism of… CONTINUE READING